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Three Dimensional Changes in the Mid-face and Naso-Labial Fold Following Injection of Calcium Hydroxyapatite

James Gatherwright MD Kyle Lineberry MD David Rowe MD
University Hospitals Case Western
2016-01-31

Presenter: Kyle Lineberry

Affidavit:
All is original work

Director Name: Hooman Soltanian MD

Author Category: Resident Plastic Surgery
Presentation Category: Clinical
Abstract Category: Aesthetics

Goals: To analyze three-dimensional volume changes in mid-face and Naso-Labial Fold (NLF) volume following malar injection of CaHa in live subjects.

Methods/Technique:CaHa was injected into supraperiosteal plane. The VECTRA 3D system was used to obtain sequential images pre- and post CaHa injections. Repeat 3D photographs were acquired at 6 months post-injection and compared to the pre-injection and immediate post-injection volume changes. Two blinded observers were asked to rate the appearance of the NLF.

Results:Injections were performed in 5 female participants, . All patients demonstrated a decrease in the NLF volume following injection with an average decrease of -0.21 cc (-0.026 to -0.498).BMI was the only significant predictor of NLF change. Larger BMIs were more predictive of large volume decrease. (p = 0.045).

Repeat measurements at 6 months demonstrated a loss of effect over time. Subjective ratings correlated with decreases in NLF volume when comparing pre- and immediate post-injection photographs (p = 0.025).

Conclusion: Three-Dimensional photographic analysis showed a relative decrease in NLF volume following malar CaHa injection. A decrease in NLF volume correlated with improved subjective evaluation of the appearance of the NLF by 2 blinded raters. This was not statistically significant at 6 months. Malar injection of CaHa may improve the appearance of the NLF by decreasing the volume in this area immediately after injection. The volume increase in the malar area had a more durable effect at 6 months while its effect on the NLF does not appear to be clinically significant at 6 months.

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