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The Potential Role of Exosomes in Aesthetic Plastic Surgery
Ying Ku, Hafsa Omer, Spencer Anderson, Ali Abtahi
Wright State University Boonshoft School of Medicine
2022-01-03
Presenter: Ying Ku
Affidavit:
The submission is original work and has not been previously presented at any major meetings.
Director Name: R. Michael Johnson
Author Category: Medical Student
Presentation Category: Clinical
Abstract Category: Aesthetics
Background: Interest and discussion on the implementation and utilization of exosomes in the field of Plastic Surgery are increasing given its broad regenerative potential and cell-free characteristic. Exosomes are heterogenous vesicles that can be derived from various cell types and exert their effects via intercellular communication through the regulation of several cell signaling pathways. The purpose of this study is to 1) review exosomes' characteristics and mechanisms of action, 2) explore potential clinical applications of exosomes in the field of Aesthetic Surgery, and 3) encourage further investigation on this emerging topic within the aesthetic community.
Methods: Comprehensive literature review was performed, identifying articles between years 2010 to 2021, using keywords exosomes, aesthetic surgery, plastic surgery, skin rejuvenation, scar reduction, hair growth, body contouring, and breast augmentation. Articles were analyzed and categorized into described sub-topics, with findings represented in table format.
Results: In current published literature, exosomes have shown to be beneficial in various animal- and cell-based models. Early clinical trials show promising results for skin aging, decreasing pigmentation, promotion of wound healing, scar reduction/enhancement, hair growth stimulation, weight loss supplementation, and enhancement of fat graft survival.
Conclusion: Despite current published data, the role of exosomes in Aesthetic Plastic Surgery is not fully established and is yet to be delineated. Therefore, continued clinical investigation is warranted to further evaluate and understand the potential impact and possible benefit on aesthetic and reconstructive patient cohorts.
