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Nano-biphasic calcium phosphate ceramic for the repair of bone defects
Majid Rezaei, Mohammad Farhadian, Ali Mohammad Rashidi, Mahshid Saeidipour, Maziar Manshaei, Masih Rezaee
Cleveland Clinic Foundation, Cleveland
2018-02-01
Presenter: Majid Rezaei
Affidavit:
I certify that the material proposed for presentation in this abstract
has not been published in any scientific journal or previously presented
at a major meeting. The majority of this work at all steps has been
done by Majid Rezaei
Director Name: Bahar Bassiri Gharb MD, PhD
Author Category: Fellow Plastic Surgery
Presentation Category: Basic Science Research
Abstract Category: Craniomaxillofacial
Calcium phosphate bioceramics has recently experienced increased interest in
bone reconstruction. Mimicking of natural structure of bone, like the
use of nano-materials, is an attractive approach for generating
scaffolds for bone regeneration. The aim of present study was to
evaluate the effect of nanonization on the Biphasic calcium phosphate
(BCP) ceramic in the repair of bone cavities in the canine mandible. A
commercial BCP was dry-milled in a high energy planetary ball mill with
zirconia balls and container. Three holes (8mm in diameter) were
outlined to the depth of cortical bone of mandibular angle of 5 dogs
bilaterally. The first hole (positive control group A,n=10)was filled in
with commercial BCP material. The second hole was loaded with the
nanonized BCP (experimental group C,n=10) and the third one was left
untreated (negative control group B,n=10). The defects were allowed to
regenerate for 8 weeks. New bone formation was greater in groups A and C
than in B. No difference was seen between group A and group C
(p=0.676). The residual bone material in group C (19.34±8.03) was as
much as one half of that in group A (38.69 ± 7.90%) (p= 0.000). The
negative control group (B) presented the highest amount of soft tissue
within the bone defects. The least percentage of marrow space was found
in the positive control group (13.23 ± 13.52). Our results depicted that
the rate of resorption increased significantly after nanonization even
though the nano-sized BCP failed to make a superior regeneration than
the ordinary BCP.
