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A Glycerin-based Wound Dressing Improves Healing Outcomes In Preclinical Porcine Model Of Maxillofacial Burn Trauma
Nandini Ghosh, Amitava Das1, Sashwati Roy, and Chandan K Sen
Indiana University
2019-02-15
Presenter: Nandini Ghosh
Affidavit:
I certify that the material proposed for presentation in this abstract has not been published in any scientific journal or previously presented at a major meeting.
Director Name: Chandan K. Sen
Author Category: Other Specialty Resident
Presentation Category: Clinical
Abstract Category: Craniomaxillofacial
Thermal injury of the face results in ectropion (epithelial-ocular junction), eversion of the lip (epithelial-oral junction), skin contracture, and excessive scar formation. The resultant facial disfiguration along with features such as oral incompetence burdens the subject socially, emotionally, and psychologically. The goal of this work was to test the healing outcomes of a glycerin-based wound dressing Elasto-Gel on a preclinical porcine model of maxillofacial burn trauma. Fourth degree burn wounds involving 50% of the face were made on female domestic Yorkshire pigs. Wounds were treated with placebo dressing (Acticoat) or Elasto-Gel once a week for 84 days. Progression of burn wound healing was followed using noninvasive imaging such as laser speckle microperfusion imaging, harmonic ultrasound Doppler imaging, and computed tomography with angiography for 3D reconstruction of face and vasculature. The application of heat resulted in a fourth degree burn with bone involvement showing severe deficits including ectropion, eversion of the oral mucosa, overt contracture and excessive scarring. Affected pigs suffered from drooling. Contracture and scarring were dramatically evident at d84 post burn. Elasto-Gel significantly accelerated the rate of wound closure during the acute phase (p<0.05; n = 3). The later phase of healing was characterized by increased regression of blood vessels upon Elasto-Gel treatment (p<0.05; n = 3). Interestingly Elasto-Gel treated wounds showed significantly less scar area at all time-points (d21, d42, d63 and d84; p<0.05; n = 3). This work constitutes maiden report on a porcine model of severe facial burn contracture. Application of Elasto-Gel dressing minimized scar outcomes.
