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Dermatofibrosarcoma Protuberans: Is There A Racial Difference In Incidence? Analysis Of Seer Database And Evaluation Of The Montefiore Experience.
Kochuba AL, Papalezova K, Shin J.
University of Pittsburgh Medical Center
2017-02-15
Presenter: Kochuba AL
Affidavit:
I agree with the above statement.
Director Name: Vu Nguyen, MD
Author Category: Fellow Plastic Surgery
Presentation Category: Clinical
Abstract Category: General Reconstruction
Background: DFSP (Dermatofibrosarcoma protuberans) is a rare sarcoma originating from the dermis. Early diagnosis, treatment, and resection are the keys to improving survival. No previous study has examined their institution's experience versus the national database. The purpose is to examine whether DFSP has a racial predilection at Montefiore compared to national data.
Methods: Retrospective review was performed nationally and at Montefiore Medical Center for all patients diagnosed with DFSP from January 2000 - December 2009. The data was compiled using Surveillance Epidemiology and End Results Program and Clinical Looking Glass. The epidemiology, treatment, and outcomes were analyzed.
Results: 3897 cases of DFSP were diagnosed nationally from 2000-2009. 68.5% were Caucasian compared to 22.2% Black. The majority of cases in Blacks and Caucasians were diagnosed in 30-49 year olds. The incidence was significantly higher in Blacks (2.1-2.3 cases per 1,000,000 people) compared to 1.2-1.3 cases in Caucasians. 41 cases of DFSP were diagnosed at Montefiore. 61% were Black, 19.5% Caucasian, and 14.6% Hispanic. The majority of cases in Blacks and Caucasians were diagnosed in 30-39 and 60-69 year olds. The incidence was significantly higher in Blacks (5.63 cases per 1,000,000 people) compared to 2 cases in Caucasians.
Conclusion: DFSP is a rare sarcoma that requires high suspicion in at risk populations. DFSP appears to have a racial predilection for African-Americans compared to Caucasians. Despite the difference in racial incidence, the surgical cure rate, long-term survival, and recurrence rate were similar amongst races. The patient data supports the racial discrepancy for African-Americans.
